Lekshmi K Edison, MS, PhD, PGDBi
Postdoctoral Associate
Department:
Department of Comparative, Diagnostic & Population Medicine
Business Phone:
(732) 353-8580
Business Email:
edison.le@ufl.edu
About Lekshmi K Edison
Dr. Lekshmi K. Edison received her Masters in Biotechnology and Masters Diploma in Bioinformatics. She earned her Doctoral degree in Biotechnology. The focus of her Doctoral study was the structural characterisation and heterologous production of Beta-glucanases from Streptomyces species. She then secured the Research – Associate fellowship from the Department of Biotechnology, Government of India and started Postdoctoral Research in the Mycobacterium Research Laboratory at Rajiv Gandhi Centre for Biotechnology (RGCB), India and focused on the CRISPR-Cas system in Mycobacterium tuberculosis. She started her research career at Kerala’s Agricultural University, before receiving her doctorate. She has more than 3 years of teaching experience in addition to 11 years of experience in research. She is a Researcher experienced with demonstrative skills in protein/ nucleic acid manipulation, gene expression analysis, protein purification/characterisation, assay development, advanced bioinformatics and statistical analysis. Currently, she focuses on veterinary diagnostic microbiology; pathogenomics of Escherichia coli and Salmonella; antimicrobial resistance, and veterinary infectious diseases.
Related Links:
Additional Positions:
Laboratory Manager
2022 – Current
·
Department of Comparative, Diagnostics and Population Medicine
Accomplishments
American Society of Microbiology (ASM) Future Leaders Mentorship Fellowship (FLMF)
2024
·
American Society of Microbiology
UF Postdoctoral Affairs- Spring 2024 Travel Award
2024
·
University of Florida
American Society of Virology Postdoctoral Scholar Travel Award (NIH Supported Grant)
2023
·
American Society of Virology
Department of Biotechnology – Research Associateship Award
2019
·
Department of Biotechnology (DBT), Government of India
Women Scientist's Back – to – Lab Research Fellowship Award
2015
·
Women Scientist Division, Kerala State Council for Science, Technology and Education (KSCSTE), State Govt. of Kerala, India
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0003-2599-7428
Areas of Interest
- Antimicrobial resistance (AMR or AR)
- Bacterial pathogenesis
- Bioinformatics
- Clinical Microbiology
- Diagnostic and molecular virology
- Infectious Diesease
- Vaccine immunology
- vaccines
Publications
Academic Articles
2025
Comparative Patho-Genomics of Salmonella enterica Serovar Enteritidis Reveal Potential Host-Specific Virulence Factors
Pathogens.
14(2)
[DOI] 10.3390/pathogens14020128.
[PMID] 40005504.
2025
Microbiome-Driven Therapeutics: From Gut Health to Precision Medicine
Gastrointestinal Disorders.
7(1)
[DOI] 10.3390/gidisord7010007.
2024
Ecotype variations and endophytic fungal diversity of aquatic angiosperm: A case study with Lagenandra toxicaria Dalz
Plant Science Today.
[DOI] 10.14719/pst.5200.
2024
Epigenetic Mechanisms Induced by Mycobacterium tuberculosis to Promote Its Survival in the Host
International Journal of Molecular Sciences.
25(21)
[DOI] 10.3390/ijms252111801.
[PMID] 39519352.
2024
Host–Pathogen Interactions during Shiga Toxin-Producing Escherichia coli Adherence and Colonization in the Bovine Gut: A Comprehensive Review
Microorganisms.
12(10)
[DOI] 10.3390/microorganisms12102009.
[PMID] 39458318.
2024
Interferon-γ/IL-2 ELISpot and mRNA Responses to the SARS-CoV2, Feline Coronavirus Serotypes 1 (FCoV1), and FCoV2 Receptor Binding Domains by the T Cells from COVID-19-Vaccinated Humans and FCoV1-Infected Cats
Methods in Molecular Biology.
2768:135-151
[DOI] 10.1007/978-1-0716-3690-9_9.
[PMID] 38502392.
2024
Isolation of Beta-Glucanase Encoding Genes from Actinobacterial Genus Streptomyces spp. and its Overexpression in Escherichia coli Heterologous System
Protocols of Actinomycetes.
82-85
[DOI] 10.1201/9781003398400-11.
2024
Pre-Harvest Non-Typhoidal Salmonella Control Strategies in Commercial Layer Chickens
Animals.
14(24)
[DOI] 10.3390/ani14243578.
[PMID] 39765482.
2024
Resistome Mapping in Foodborne Pathogens: Understanding Role in the Transmission Dynamics of Resistance Genes
Applied Microbiology.
4(4):1476-1492
[DOI] 10.3390/applmicrobiol4040102.
2023
Biofuels from cyanobacteria -a metabolic engineering approach
Plant Science Today.
[DOI] 10.14719/pst.2505.
2023
Both Feline Coronavirus Serotypes 1 and 2 Infected Domestic Cats Develop Cross-Reactive Antibodies to SARS-CoV-2 Receptor Binding Domain: Its Implication to Pan-CoV Vaccine Development
Viruses.
15(4)
[DOI] 10.3390/v15040914.
[PMID] 37112894.
2023
Comparative Transcriptome Analysis of Shiga Toxin-Producing Escherichia coli O157:H7 on Bovine Rectoanal Junction Cells and Human Colonic Epithelial Cells during Initial Adherence
Microorganisms.
11(10)
[DOI] 10.3390/microorganisms11102562.
[PMID] 37894220.
2023
Rv1255c, a dormancy-related transcriptional regulator of TetR family in Mycobacterium tuberculosis, enhances isoniazid tolerance in Mycobacterium smegmatis
The Journal of Antibiotics.
[DOI] 10.1038/s41429-023-00661-8.
2023
Safety Issues, Environmental Impacts, and Health Effects of Biopolymers
Handbook of Biopolymers.
1469-1495
[DOI] 10.1007/978-981-19-0710-4_54.
2022
Application of Codon Optimization and Recombinant Expression of Beta-Glucanases
Microbial Beta Glucanases.
157-170
[DOI] 10.1007/978-981-19-6466-4_10.
2022
Beta-Glucanase in Breweries
Microbial Beta Glucanases.
85-98
[DOI] 10.1007/978-981-19-6466-4_6.
2022
Beta-Glucanases in Animal Nutrition
Microbial Beta Glucanases.
73-83
[DOI] 10.1007/978-981-19-6466-4_5.
2022
Beta-Glucanases: An Introduction, Marketing Dynamics and Industrial Applications
Microbial Beta Glucanases.
1-14
[DOI] 10.1007/978-981-19-6466-4_1.
2022
Biotechnological Avenues in Hybrid Beta-Glucanases
Microbial Beta Glucanases.
187-195
[DOI] 10.1007/978-981-19-6466-4_12.
2022
Chrysomycin A inhibits the topoisomerase I of Mycobacterium tuberculosis.
The Journal of antibiotics.
75(4):226-235
[DOI] 10.1038/s41429-022-00503-z.
[PMID] 35136191.
2022
Exploitation of Actinobacteria for Beta-Glucanolytic Enzymes—Screening and Characterization
Microbial Beta Glucanases.
117-134
[DOI] 10.1007/978-981-19-6466-4_8.
2022
Industrial Production and Purification of Recombinant Beta-Glucanases
Microbial Beta Glucanases.
171-185
[DOI] 10.1007/978-981-19-6466-4_11.
2022
Mycobacterium tuberculosis transcriptional regulator Rv1019 is upregulated in hypoxia and negatively regulates Rv3230c‐Rv3229c operon encoding enzymes in the oleic acid biosynthetic pathway.
The FEBS Journal.
[DOI] 10.1111/febs.16647.
2022
Structural Characterization of Beta-Glucanase from Actinobacteria
Microbial Beta Glucanases.
135-155
[DOI] 10.1007/978-981-19-6466-4_9.
2022
Structure and Classification of Beta-Glucanases
Microbial Beta Glucanases.
15-32
[DOI] 10.1007/978-981-19-6466-4_2.
2020
A Strategic Production Improvement of Streptomyces Beta Glucanase Enzymes with Aid of Codon Optimization and Heterologous Expression
Biosciences Biotechnology Research Asia.
17(03):587-599
[DOI] 10.13005/bbra/2862.
2020
Actinobacterial Nanoparticles: Green Synthesis, Evaluation and Applications
Nanotechnology in the Life Sciences.
371-384
[DOI] 10.1007/978-3-030-39246-8_20.
2020
Beta-Glucanolytic Soil Actinomycetes: Diversity and Applications
Rhizosphere Microbes.
471-482
[DOI] 10.1007/978-981-15-9154-9_19.
2020
Functional screening of β-Glucanase Producing Actinomycetes Strains from Western Ghats ecosystems of Kerala, India
Indian Journal of Applied and Pure Biology.
35(2):255-270
[DOI] 10.1101/2020.04.11.036731.
2020
In silico perceptions in structural elucidation of Exo-ß-1,4-glucanase and Endo-ß-1,3-glucanase from Streptomyces spp.
Journal of Applied Biology & Biotechnology.
[DOI] 10.7324/jabb.2020.80612.
2019
Enzyme Nanoparticles: Microbial Source, Applications and Future Perspectives
Nanotechnology in the Life Sciences.
61-76
[DOI] 10.1007/978-3-030-16534-5_4.
2019
Phylogenetic Analysis of Beta-Glucanase Producing Actinomycetes Strain TBG-CH22 – A Comparison of Conventional and Molecular Morphometric Approach
International Journal of Advanced Biological and Biomedical Research.
7(2):113-122
[DOI] 10.33945/sami/ijabbr.2019.2.2.
2018
Microbial Beta Glucanase in Agriculture
Advances in Microbial Biotechnology.
53-72
[DOI] 10.1201/9781351248914-2.
2017
Educating Biodiversity
Bioresources and Bioprocess in Biotechnology.
143-165
[DOI] 10.1007/978-981-10-3573-9_7.
2017
ENZYME ACTIVITY PROFILING OF EXO -β-1,4- GLUCANASE, ENDO-β-1,3- GLUCANASE AND PROTEASE IN STREPTOMYCES SPECIES FROM HIGHLAND, MIDLAND AND LOWLAND AREAS OF KERALA, INDIA.
International Journal of Advanced Research.
5(2):2431-2444
[DOI] 10.21474/ijar01/3427.
2017
Exploitation of Fungi and Actinobacteria for Sustainable Agriculture
Microbial Biotechnology.
135-162
[DOI] 10.1007/978-981-10-6847-8_6.
Presentations
2022-12-13
Unexpectedly high cross-reactivity between the receptor binding domains of SARS-CoV-2 and feline coronaviruses.
Regional
/
Other.
Poster.
Austin Cary Learning Center, University of Florida
2023-02-16
Cross-reactivity between Receptor Binding Domains of Feline Coronaviruses and SARS-CoV-2: The Foundation to Developing Minimalistic Pan-CoV Vaccines for Animals and Humans.
Regional
/
Other.
Poster.
2023-04-13
Profound Cross-reactivity between Receptor Binding Domains of Feline Coronavirus Serotypes 1 and 2 with SARS-CoV-2: Its Impact on Diagnostics and Pan-CoV Vaccine Development.
Regional
/
Other.
Poster.
2023-06-24
High Cross-reactivity between Receptor Binding Domains of Feline Coronavirus Serotypes 1 and 2 with SARS-CoV-2: Its Impact on Diagnostics and Pan-CoV Vaccine Development.
International
/
Other.
Poster.
University of Georgia, Athens, United States.
2023-05-16
Comprehensive Screening of Antimicrobial Resistance in Avian Pathogenic E. coli Isolated from Poultry through Whole Genome Sequencing.
National
/
Other.
Poster.
University of Florida
2024-06-13
Differential Expression of Virulence Genes in Shiga Toxin Producing Escherichia coli O157:h7 During Initial Colonization of Human Colonic Epithelial and Rectoanal Junction Cells Revealed Host Specific Adaptations
International
/
Other.
Poster.
Georgia World Congress Center, Atlanta
2024-06-13
The Starvation-Inducible Lipoprotein (SLP) Plays a Role in Escherichia coli O157:H7 Adherence to the Bovine Rectoanal Junction
International
/
Other.
Poster.
Georgia World Congress Center, Atlanta
Grants
Sep 2023
ACTIVE
Developing a vaccine against spotty liver diseased caused by Campylobacter hepaticus in commercial layer chickens
Role: Other
Funding: US DEPT OF AG NATL INST OF FOOD AND AG
Education
Post Doctoral
2021-2022
·
College of Medicine, University of Florida
Post Doctoral
2019-2021
·
Rajiv Gandhi Centre for Biotechnology (RGCB), Kerala, India
PhD – Biotechnology
2019
·
University of Kerala, Kerala, India
Masters Diploma – Bioinformatics
2015
·
Bharathiyar University, Tamil Nadu, India
Masters – Biotechnology
2006
·
Mahatma Gandhi University, Kerala, India
Bachelor Degree – Zoology
2004
·
Mahatma Gandhi University, Kerala, India
Contact Details
Phones:
- Business:
- (732) 353-8580
Emails:
- Business:
- edison.le@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100123
2015 SW 16TH AVE
GAINESVILLE FL 32610