Michael J Dark,
Director & Clinical Associate Professor
Department: Department of Comparative, Diagnostic & Population Medicine
Business Phone: (352) 294-4138
Business Email: firstname.lastname@example.org
Barbara Jean Thompson Award for Outstanding Service2018 · Davis / Thompson Foundation
Member, Board of Directors2017-2025 · Davis / Thompson Foundation
VEM5115 Veterinary Histology
VEM5851 Senior Clk App Pathol
VEM5751 Core Clk Appl Pathol
VEM5571 Emerging Diseases
VEM5165 Large Anim Pathology
VEM5162 Vet Pathology 2
VEM5164 Small Anim Pathology
VME7980 Research for Doctoral Dissertation
DiplomateAmerican College of Veterinary Pathologists
Veterinary Pathology, including studying the pathology of a variety of conditions in animals in an attempt to better model human disease.
Discovery and diagnosis of diseases in animals
Bacterial genomics and vector-borne diseases
Bacterial genome sequencing and bioinformatics
Rickettsial diseases such as Anaplasma marginale and other model systems
Disease research, including how to better use archived samples for genetic research
Examining alternative fixatives for DNA research
Determining the maximum useful sample age for DNA recovery from diagnostic tissue samples.
Animals as model systems for disease
Pathology of a variety of conditions in animals in an attempt to better model human disease.
Open Researcher and Contributor ID (ORCID)
Chronic intermittent dyschezia in a 10-year-old spayed female domestic shorthair cat.
Journal of the American Veterinary Medical Association. 261(6):1-4 [DOI] 10.2460/javma.22.11.0502. [PMID] 36626289.
Detection of Necrosis in Digitised Whole-Slide Images for Better Grading of Canine Soft-Tissue Sarcomas Using Machine-Learning
Veterinary Sciences. 10(1) [DOI] 10.3390/vetsci10010045. [PMID] 36669046.
Mitosis domain generalization in histopathology images – The MIDOG challenge.
Medical image analysis. 84 [DOI] 10.1016/j.media.2022.102699. [PMID] 36463832.
Deep learning for necrosis detection using canine perivascular wall tumour whole slide images.
Scientific reports. 12(1) [DOI] 10.1038/s41598-022-13928-1. [PMID] 35739267.
Magnetic resonance imaging of the normal equine pituitary gland
Veterinary Radiology & Ultrasound. 63(4):450-455 [DOI] 10.1111/vru.13072.
RNA in situ hybridisation as a molecular diagnostic technique targeting IBA-1 and CD204 in canine histiocytic sarcoma.
Veterinary medicine and science. 8(4):1400-1408 [DOI] 10.1002/vms3.795. [PMID] 35339118.
Canine osteosarcoma checkpoint expression correlates with metastasis and T-cell infiltrate.
Veterinary immunology and immunopathology. 232 [DOI] 10.1016/j.vetimm.2020.110169. [PMID] 33387703.
Evaluation of ponatinib in vitro effect in three canine mast cell tumor cell lines expressing FGFR-1, PDGFR-α, and VEGFR-2
The Veterinary Journal. 269 [DOI] 10.1016/j.tvjl.2021.105621.
International Guidelines for Veterinary Tumor Pathology: A Call to Action.
Veterinary pathology. 58(5):766-794 [DOI] 10.1177/03009858211013712. [PMID] 34282984.
Retrospective study of gross and histopathologic lesions associated with closed chest cardiopulmonary resuscitation in dogs.
The Journal of small animal practice. 62(9):750-755 [DOI] 10.1111/jsap.13349. [PMID] 33987841.
Feasibility and efficacy of ultrasonographic and laparoscopic guidance for microwave ablation of clinically normal canine ovaries.
American journal of veterinary research. 81(9):747-754 [DOI] 10.2460/ajvr.81.9.747. [PMID] 33112170.
Primary Hyperparathyroidism in a Quarter Horse Mare Associated With a Chief Cell Adenoma
Journal of Equine Veterinary Science. 95 [DOI] 10.1016/j.jevs.2020.103302.
SDHB and SDHA Immunohistochemistry in Canine Pheochromocytomas
Animals. 10(9) [DOI] 10.3390/ani10091683. [PMID] 32957698.
What is your diagnosis? Cutaneous mass from a Shar‐Pei Dog
Veterinary Clinical Pathology. 49(2):365-366 [DOI] 10.1111/vcp.12854.
Complete Urogenital and Anorectal Duplication in a Dog.
Case reports in veterinary medicine. 2019 [DOI] 10.1155/2019/3696978. [PMID] 30941228.
Fine-needle aspirate of a large mass in the ventral peritoneal space of a dog.
Veterinary clinical pathology. 48(2):355-357 [DOI] 10.1111/vcp.12716. [PMID] 30938837.
Immunogenicity and Efficacy of a Novel Multi-Antigenic Peptide Vaccine Based on Cross-Reactivity between Feline and Human Immunodeficiency Viruses.
Viruses. 11(2) [DOI] 10.3390/v11020136. [PMID] 30717485.
Laparoscopic access to the liver and application of laparoscopic microwave ablation in 2 dogs with liver neoplasia.
Veterinary surgery : VS. 48(S1):O91-O98 [DOI] 10.1111/vsu.13153. [PMID] 30666685.
Pathology in Practice.
Journal of the American Veterinary Medical Association. 255(3):309-312 [DOI] 10.2460/javma.255.3.309. [PMID] 31298650.
Understanding the Efficiency of Splenic Hemangiosarcoma Diagnosis Using Monte Carlo Simulations.
Veterinary pathology. 56(6):856-859 [DOI] 10.1177/0300985819868732. [PMID] 31422751.
Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model.
Human gene therapy. Clinical development. 29(2):90-100 [DOI] 10.1089/humc.2017.142. [PMID] 29869540.
Histologic characterization of eosinophilic encephalitis in horses in Florida.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 30(3):442-446 [DOI] 10.1177/1040638718763877. [PMID] 29528809.
Self-Complementary Adeno-Associated Virus-Mediated Interleukin-1 Receptor Antagonist Gene Delivery for the Treatment of Osteoarthritis: Test of Efficacy in an Equine Model.
Human gene therapy. Clinical development. 29(2):101-112 [DOI] 10.1089/humc.2017.143. [PMID] 29869535.
Viral Enrichment Methods Affect the Detection but Not Sequence Variation of West Nile Virus in Equine Brain Tissue.
Frontiers in veterinary science. 5 [DOI] 10.3389/fvets.2018.00318. [PMID] 30619900.
A retrospective study of the prevalence of calcium oxalate crystals in veterinary Aspergillus cases.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 29(1):51-58 [DOI] 10.1177/1040638716672254. [PMID] 27852812.
Cutaneous iridophoroma in a Green iguana (Iguana iguana).
Veterinary clinical pathology. 46(4):625-628 [DOI] 10.1111/vcp.12536. [PMID] 28815678.
Determination of metabolic resistance mechanisms in pyrethroid-resistant and fipronil-tolerant brown dog ticks.
Medical and veterinary entomology. 31(3):243-251 [DOI] 10.1111/mve.12240. [PMID] 28639697.
Microwave ablation for treatment of hepatic neoplasia in five dogs.
Journal of the American Veterinary Medical Association. 250(1):79-85 [DOI] 10.2460/javma.250.1.79. [PMID] 28001112.
Chordomas at High Prevalence in the Captive Population of the Endangered Perdido Key Beach Mouse (Peromyscus polionotus trissyllepsis).
Veterinary pathology. 53(1):163-9 [DOI] 10.1177/0300985815575051. [PMID] 25791038.
Determining the utility of veterinary tissue archives for retrospective DNA analysis.
PeerJ. 4 [DOI] 10.7717/peerj.1996. [PMID] 27168995.
Superinfection Exclusion of the Ruminant Pathogen Anaplasma marginale in Its Tick Vector Is Dependent on the Time between Exposures to the Strains.
Applied and environmental microbiology. 82(11):3217-3224 [DOI] 10.1128/AEM.00190-16. [PMID] 26994084.
Comparison of histomorphology and DNA preservation produced by fixatives in the veterinary diagnostic laboratory setting.
PeerJ. 2 [DOI] 10.7717/peerj.377. [PMID] 24860702.
Efficacy of slow-release tags impregnated with aggregation-attachment pheromone and deltamethrin for control of Amblyomma variegatum on St. Kitts, West Indies.
Parasites & vectors. 7 [DOI] 10.1186/1756-3305-7-182. [PMID] 24731252.
Evaluation of the effect of formalin fixation on skin specimens in dogs and cats.
PeerJ. 2 [DOI] 10.7717/peerj.307. [PMID] 24688882.
Anorectal anatomy and imaging techniques.
Gastroenterology clinics of North America. 42(4):701-12 [DOI] 10.1016/j.gtc.2013.09.008. [PMID] 24280395.
Gastrointestinal leiomyosarcoma in a pygmy sperm whale (Kogia breviceps).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 44(3):744-8 [PMID] 24063105.
scAAV-mediated gene transfer of interleukin-1-receptor antagonist to synovium and articular cartilage in large mammalian joints.
Gene therapy. 20(6):670-7 [DOI] 10.1038/gt.2012.81. [PMID] 23151520.
T Cell Rich, B Cell Lymphoma in the Small Colon of a Yearling Horse
Equine Veterinary Education. 25(2):74-78 [DOI] 10.1111/j.2042-3292.2012.00398.x.
Whole-genome sequencing in bacteriology: state of the art.
Infection and drug resistance. 6:115-23 [DOI] 10.2147/IDR.S35710. [PMID] 24143115.
Comparative genomics and transcriptomics of trait-gene association.
BMC genomics. 13 [DOI] 10.1186/1471-2164-13-669. [PMID] 23181781.
Determining the repertoire of immunodominant proteins via whole-genome amplification of intracellular pathogens.
PloS one. 7(4) [DOI] 10.1371/journal.pone.0036456. [PMID] 22558468.
Ocular and olfactory forebrain abnormalities within a neonatal alpaca (Vicugna pacos).
The Journal of veterinary medical science. 74(7):945-7 [PMID] 22446393.
Multistrain genome analysis identifies candidate vaccine antigens of Anaplasma marginale.
Vaccine. 29(31):4923-32 [DOI] 10.1016/j.vaccine.2011.04.131. [PMID] 21596083.
Conservation in the face of diversity: multistrain analysis of an intracellular bacterium.
BMC genomics. 10 [DOI] 10.1186/1471-2164-10-16. [PMID] 19134224.
Evidence for persistent Bovine viral diarrhea virus infection in a captive mountain goat (Oreamnos americanus).
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 20(6):752-9 [PMID] 18987224.
Granulocytopenia associated with thymoma in a domestic shorthaired cat.
Journal of the American Animal Hospital Association. 44(4):210-7 [PMID] 18593858.
Safety and efficacy of intramuscular propofol administration in rats.
Veterinary anaesthesia and analgesia. 35(6):495-500 [DOI] 10.1111/j.1467-2995.2008.00418.x. [PMID] 18980630.
Superinfection as a driver of genomic diversification in antigenically variant pathogens.
Proceedings of the National Academy of Sciences of the United States of America. 105(6):2123-7 [DOI] 10.1073/pnas.0710333105. [PMID] 18252822.
Immunogenicity of Anaplasma marginale type IV secretion system proteins in a protective outer membrane vaccine.
Infection and immunity. 75(5):2333-42 [PMID] 17339347.
Differential expression and sequence conservation of the Anaplasma marginale msp2 gene superfamily outer membrane proteins.
Infection and immunity. 74(6):3471-9 [PMID] 16714578.
Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins.
Proceedings of the National Academy of Sciences of the United States of America. 102(3):844-9 [PMID] 15618402.
Autosomal recessive severe combined immunodeficiency of Jack Russell terriers.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 14(3):194-204 [PMID] 12033674.
Diplomate2011 · American College of Veterinary Pathologists
PhD, Veterinary Microbiology & Pathology2008 · Washington State University
Doctor of Veterinary Medicine2001 · Michigan State University
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